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ECD Applications

e-MSion’s ExD cell provides you with a range of extended capabilities for running your experiments. The tunable electron energy (0.3-100 eV) allows to analyze compounds from small lipids up to multimeric megadalton complexes.

Typical applications are:

  • top-down analysis of proteins, biologics and non-covalent complexes
  • analysis of labile or difficult post-translational modifications (PTM’s) such as phosphorylations (including those on Lys, Arg and His residues), sulfatations, deamidation (Asp/isoAsp differentiation) or γ-Carboxyglutamate
  • Hydrogen/deuterium exchange (HDX) for protein structure characterization
  • collisional induced unfolding for protein structure analysis
  • de-novo sequencing (Leu/Ile differentiation)
  • glycan intraring cleavage for connectivity analysis
  • lipid fragmentation

Some of the applications require the usage of IMS in combination with ECD and are thus exclusively available on Waters Synapt technology.

Download further information on ECD applications and upgrades

Excellent service, as always. Many thanks Alex!

Anonymous from feedback form after LTQ-Orbitrap service

I would like to take the opportunity to thank you for the repair of our Quattro Micro and subsequent ‘hands on’ training course. The training course was very useful, generating positive feedbacks from the attendees. We look forward to receiving the training course certificates.

Dr. Nancy Weisbach
Across Barriers GmbH

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Boris Krichel
Hamburg

The team of MS Vision has recently helped us to relocate our entire mass spectrometry lab, including five Orbitrap instruments (three Q Exactive series, one Elite and one Fusion) within the campus of Karolinska Institutet. Both the preparation and execution of this delicate operation was performed with absolute profession and accuracy. After the careful move, it took only two days to get all systems up and running like they would have never been down for a second. Needless to say how grateful we are for MS Vision for this excellent job!

Akos Vegvari, PhD
Proteomics Biomedicum, Karolinska Institutet

Perfect service!

Anonymous from feedback form after LTQ-Orbitrap XL relocation
Martin-Luther-Universität Halle-Wittenberg

MS Vision is our long lasting services partner for the maintenance and troubleshooting of our entire fleet of LC-MS/MS instruments. For us, their eagerness to extend their portfolio with new services and collaboratively identify ways of improvements is very much appreciated and fundamental in the reduction of instrument downtime that has been achieved.

Niels Martha
TLR International Laboratories

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Anonymous from feedback form after Waters QTOF Ultima maintenance

Very friendly and competent. We got a few new tips for our cleaning routine.

Anonymous from feedback form after Sciex API4000 maintenance
LMU Munich

Excellent and very competent service as always. We are very satisfied. Thanks again that you made it possible at such short notice.

Anonymous from feedback form after Waters Synapt maintenance
University of Freiburg

We are super happy that Jerre could fix our high mass QTOF II! It was a big task this time, but now I am confident we will be able to get good data with the instrument for many more years! The service is absolutely fantastic!!!

Anonymous from feedback form after High mass QTOF2 repair
Martin-Luther-Universität Halle-Wittenberg

Since last Wednesday we ran around 100 samples, everything is perfect (better sensitivity and linear dynamic range).  I have checked some data back to the last October, since I know what I am looking for, it seems that the charging problems started around December/January. Next time I will realize it much earlier.  Thank you both for your cleaning effort 😉

 

Manuel Mazenauer
Labor Veritas AG

I would like to thank you again for your efforts in setting up our High Mass Q-Tof-MS and in introducing my students to the basic operating principles of the instrument. We performed the first measurements this week, which went really well. You did a great job and we are very happy with our new toy.

Prof. Dr. Andrea Sinz
Martin-Luther University Halle-Wittenberg

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Dominic Helm
EMBL

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Anonymous from feedback form after Xevo QTOF G2-XS repair
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