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ECD Applications

e-MSion’s ExD cell provides you with a range of extended capabilities for running your experiments. The tunable electron energy (0.3-100 eV) allows to analyze compounds from small lipids up to multimeric megadalton complexes.

Typical applications are:

  • top-down analysis of proteins, biologics and non-covalent complexes
  • analysis of labile or difficult post-translational modifications (PTM’s) such as phosphorylations (including those on Lys, Arg and His residues), sulfatations, deamidation (Asp/isoAsp differentiation) or γ-Carboxyglutamate
  • Hydrogen/deuterium exchange (HDX) for protein structure characterization
  • collisional induced unfolding for protein structure analysis
  • de-novo sequencing (Leu/Ile differentiation)
  • glycan intraring cleavage for connectivity analysis
  • lipid fragmentation

Some of the applications require the usage of IMS in combination with ECD and are thus exclusively available on Waters Synapt technology.

Download further information on ECD applications and upgrades

Since last Wednesday we ran around 100 samples, everything is perfect (better sensitivity and linear dynamic range).  I have checked some data back to the last October, since I know what I am looking for, it seems that the charging problems started around December/January. Next time I will realize it much earlier.  Thank you both for your cleaning effort 😉

 

Manuel Mazenauer
Labor Veritas AG

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EMBL

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Across Barriers GmbH

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LMU Munich

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Martin-Luther University Halle-Wittenberg

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Hamburg

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Akos Vegvari, PhD
Proteomics Biomedicum, Karolinska Institutet

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Martin-Luther-Universität Halle-Wittenberg

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TLR International Laboratories

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University of Freiburg

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Martin-Luther-Universität Halle-Wittenberg
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